Differin Cream & Gel

differin gel and cream

Differin is ideal for daily use in either a gel or cream to remove acne and return skin back to its healthy tone and texture.

Use the cream on sensitive or dry skin and the gel on normal or oily skin.

Do not use when pregnant or breastfeeding.

Get started


Our job is to look after you.

Contact us if you require any assistance from our professional customer service team

What is Differin?

Differin can be used as a gel or cream for the treatment of mild to moderate acne. It contains the active ingredient adapalene, a form of Vitamin A. The cream is recommended for sensitive or dry skin and the gel for normal or oily skin.

Adapalene belongs to a group of medicines called retinoids (which includes tretinoin) and helps to reduce inflammation and black and white head formation on the outer layer of the skin. It unblocks pores and promotes skin cell renewal to help prevent spots. Differin is ideal for daily use in either a gel or cream to remove acne and return skin back to its healthy tone and texture.

How do I apply Differin?

Apply a thin layer of gel or cream evenly over the acne affected areas only once daily at bedtime.

Apply to all the parts of your face affected by acne 20 minutes after washing your face. Do not apply near or to the eyes, lips, nostrils or other sensitive areas. The gel should be applied to clean, dry skin and take care to wash your hands thoroughly before and after use.

Do not apply to broken skin.

How long does it take to see results?

You may not see results for up to four weeks. It is important to be consistent in your application of this medication in order for it to work properly.

Your acne may flare up after stopping treatment, to avoid this you may have to apply a smaller dose of the acne treatment for some years after to keep the condition under control.

Is there anybody who can't use it?

Differin is not suitable for those with a hypersensitivity to any of the ingredients. Do not use in pregnancy or breastfeeding. Avoid sunlight and UV lamps while using this medicine. Do not use other acne products containing retinoids or benzoyl peroxide while using it or products that are irritating, drying or exfoliating to the skin.

Are there any side-effects?

Some people can experience a burning sensation, dryness, scaling and redness when they first use this medicine. This presents worst during the first week of use and then tends to settle.

For a full list of potential side-effects please see the Patient Information Leaflet below.

Are there any contra-indications or interactions?

You should not use Differin if you think you might be pregnant, are pregnant or breastfeeding.

You can use other topical acne medications alongside Adapalene, however they should be used in the morning and your Adapalene at night. You should avoid any products that contain tretinoin, isotretinoin or tazarotene.

Medically reviewed by
4 April 2022

with regular use you can return your skin back to its healthy state

more conditions we can help with

Emergency Contraception

weight loss

We use cookies to help us provide you with a better service, but do not track anything that can be used to personally identify you.

If you prefer us not to set these cookies, please visit our Cookie Settings page or continue browsing our site to accept them.